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Contraindicated (one)pentobarbital will lessen the level or impact of dienogest/estradiol valerate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Girls mustn't pick estradiol valerate/dienogest as their contraceptive while applying sturdy CYP3A4 inducers as a result of probable reduce in contraceptive efficacy.pentobar